In this paper, we report our studies of a dual relay catalytic protocol for regioselective arylation of amines at their unactivated β-C(sp3 )-H bond. The strategy merges reversible dehydrogenation of amines by Rh catalysis and C-H functionalisation of transient imines by Pd catalysis, enabling the reactions for previously inaccessible starting materials. In a broader sense, this study demonstrates new opportunities in dual relay catalysis involving hydrogen borrowing chemistry, previously explored in the functionalisation of alcohols, to execute otherwise challenging transformations for amines, commonly present in natural products, pharmaceuticals, biologically active molecules, and functional materials.

https://pubs.rsc.org/en/content/articlepdf/2025/SC/D4SC06806H?page=search

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