The hydroformylation of simple aliphatic alkenes, such as propylene, is one of the largest homogenous catalyzed processes in the chemical industry, producing over 10 million metric tons of different aldehydes each year. Typically, such processes are catalyzed by Co or Rh catalysts, yielding mostly linear aldehydes, such as n-butanal. However, the increasing demand for branched aldehydes, such as isobutanal, triggered further investigation to develop efficient isoselective protocols, which remain scarce. In this Synpacts article, we discuss our recent work on iodide-assisted Pd catalysis as an attractive alternative strategy for the development of isoselective methods. This article is presented considering the state of the art for Rh-catalyzed processes. Additionally, we discuss the limitations and challenges that need to be addressed in order to successfully transfer the technology to industry.
In this article we highlight the recent studies by the laboratories of Hartwig, Scott, and Guironnet, which demonstrated that ingenious cascades of reactions driven by catalysts operating in concert enable conversion of ethylene and polyethylene (PE) materials, the largest plastic waste contributor, into propylene, the valuable olefin used in the synthesis of various chemicals and commodity materials.
Given that alcohol moieties are present in a great diversity of valuable fine chemicals from nature and synthesis, methods enabling their structure diversification are highly sought after. Catalysis proved to enable the development of new transformations that are beyond the inherent reactivity of alcohols. However, modifying the structure of alcohols at certain unbiased positions remains a major challenge or requires tedious multistep procedures. Recently, increased attention has been given to multicatalyis, which combines multiple reactions and catalysts within one system, creating room for discovering previously inaccessible reactivities or increasing the overall efficiency of multistep transformations. This feature article focuses on demonstrating various aspects of devising such multicatalytic systems that modify the structure of alcohol-containing compounds. Special attention is given to highlighting the challenges and advantages of multicatalysis, and in a broader context discussing how the field of catalysis may progress toward more complex systems.
After an excellent presentation and a thorough scientific discussion with the jury members – Prof. Martin Oestreich, Dr. Adrien Quintard, Dr. Stéphane Bellemin-Laponnaz, Lukas successfully defended his PhD thesis and was granted a doctorate title. Congratulations and good luck for the future! Special thanks to the jury members!
Our recent perspective on ‘Recent Trends in Group 9–Catalyzed C−H Borylation Reactions: Different Strategies to Control Site-, Regio-, and Stereoselectivity.‘ has been selected for the cover of the ‘Bürgenstock Special Issue 2021 – Future Stars in Organic Chemistry’.